Long-term Diet Quality and Gut Microbiome Functionality: A Prospective, Shotgun Metagenomic Study among Urban Chinese Adults.

ABSTRACT:

Background

Diet is known to affect human gut microbiome composition; yet, how diet affects gut microbiome functionality remains unclear.

Objective

We compared the diversity and abundance/presence of fecal microbiome metabolic pathways among individuals according to their long-term diet quality.

Methods

In 2 longitudinal cohorts, we assessed participants' usual diets via repeated surveys during 1996-2011 and collected a stool sample in 2015-2018. Participants who maintained a healthy or unhealthy diet (i.e., stayed in the highest or lowest quintile of a healthy diet score throughout follow-up) were selected. Participants were excluded if they reported a history of cancer, cardiovascular disease, diabetes, or hypertension; had diarrhea or constipation in the last 7 d; o

SUBMITTER: Yu D 

PROVIDER: S-EPMC8068758 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature