Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events.

ABSTRACT:

Background

Intensive systolic blood pressure (SBP) treatment prevents cardiovascular disease (CVD) events in patients with high CVD risk on average, though benefits likely vary among patients.

Objectives

The aim of this study was to predict the magnitude of benefit (reduced CVD and all-cause mortality risk) along with adverse event (AE) risk from intensive versus standard SBP treatment.

Methods

This was a secondary analysis of SPRINT (Systolic Blood Pressure Intervention Trial). Separate benefit outcomes were the first occurrence of: 1) a CVD composite of acute myocardial infarction or other acute coronary syndrome, stroke, heart failure, or CVD death; and 2) all-cause mortality. Treatment-related AEs of interest included hypotension, syncope, bradycardia, electrolyte

SUBMITTER: Bress AP 

PROVIDER: S-EPMC8068761 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature