Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China during 2016-2018.

ABSTRACT: Classical swine fever (CSF) is a highly contagious disease of swine caused by classical swine fever virus (CSFV). For decades the disease has been controlled in China by a modified live vaccine (C-strain) of genotype 1. The emergent genotype 2 strains have become predominant in China in the past years that are genetically distant from the vaccine strain. Here, we aimed to evaluate the current infectious status of CSF, and for this purpose 24 isolates of CSFV were identified from different areas of China during 2016-2018. Phylogenetic analysis of NS5B, E2 and full genome revealed that the new isolates were clustered into subgenotype 2.1d and 2.1b, while subgenotype 2.1d was predominant. Moreover, E2 and E^rns displayed multiple variations in neutralizing epitope regions. Furthermo

SUBMITTER: Fatima M 

PROVIDER: S-EPMC8069065 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature