LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in Leishmania.

ABSTRACT: Leishmania parasites cycle between sand fly vectors and mammalian hosts, transforming from extracellular promastigotes that reside in the vectors' alimentary canal to obligatory intracellular non-motile amastigotes that are harbored by macrophages of the mammalian hosts. The transition between vector and host exposes them to a broad range of environmental conditions that induces a developmental program of gene expression, with translation regulation playing a key role. The Leishmania genome encodes six paralogs of the cap-binding protein eIF4E. All six isoforms show a relatively low degree of conservation with eIF4Es of other eukaryotes, as well as among themselves. This variability could suggest that they have been assigned discrete roles that could contribute to their survi

SUBMITTER: Shrivastava R 

PROVIDER: S-EPMC8069130 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature