Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients.

ABSTRACT: Alzheimer's disease is a progressive, devastating, and irreversible brain disorder that, day by day, destroys memory skills and social behavior. Despite this, the number of known genes suitable for discriminating between AD patients is insufficient. Among the genes potentially involved in the development of AD, there are the chitinase-like proteins (CLPs) CHI3L1, CHI3L2, and CHID1. The genes of the first two have been extensively investigated while, on the contrary, little information is available on CHID1. In this manuscript, we conducted transcriptome meta-analysis on an extensive sample of brains of healthy control subjects (n = 1849) (NDHC) and brains of AD patients (n = 1170) in order to demonstrate CHID1 involvement. Our analysis revealed an inverse correlation between the brain CHID

SUBMITTER: Castrogiovanni P 

PROVIDER: S-EPMC8069241 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature