Ontology highlight
ABSTRACT:
SUBMITTER: Davenport CF
PROVIDER: S-EPMC8069345 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Davenport Colin F CF Scheithauer Tobias T Dunst Alessia A Bahr Frauke Sophie FS Dorda Marie M Wiehlmann Lutz L Tran Doan Duy Hai DDH
International journal of molecular sciences 20210411 8
Downregulation of multiple tumor suppressor genes (TSGs) plays an important role in cancer formation. Recent evidence has accumulated that cancer progression involves genome-wide alteration of epigenetic modifications, which may cause downregulation of the tumor suppressor gene. Using hepatocellular carcinoma (HCC) as a system, we mapped 5-methylcytosine signal at a genome-wide scale using nanopore sequencing technology to identify novel TSGs. Integration of methylation data with gene transcript ...[more]