Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics.

ABSTRACT: Since coronavirus disease 2019 (COVID-19) is a serious new worldwide public health crisis with significant morbidity and mortality, effective therapeutic treatments are urgently needed. Drug repurposing is an efficient and cost-effective strategy with minimum risk for identifying novel potential treatment options by repositioning therapies that were previously approved for other clinical outcomes. Here, we used an integrated network-based pharmacologic and transcriptomic approach to screen drug candidates novel for COVID-19 treatment. Network-based proximity scores were calculated to identify the drug-disease pharmacological effect between drug-target relationship modules and COVID-19 related genes. Gene set enrichment analysis (GSEA) was then performed to determine whether drug candidates

SUBMITTER: Liu DY 

PROVIDER: S-EPMC8069812 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature