Untargeted Metabolomics Insights into Newborns with Congenital Zika Infection.

ABSTRACT: Zika virus (ZIKV), an emerging virus belonging to the Flaviviridae family, causes severe neurological clinical complications and has been associated with Guillain-Barré syndrome, fetal abnormalities known collectively as congenital Zika syndrome, and microcephaly. Studies have shown that ZIKV infection can alter cellular metabolism, directly affecting neural development. Brain growth requires controlled cellular metabolism, which is essential for cell proliferation and maturation. However, little is known regarding the metabolic profile of ZIKV-infected newborns and possible associations related to microcephaly. Furthering the understanding surrounding underlying mechanisms is essential to developing personalized treatments for affected individuals. Thus, metabolomics, the study of the met

SUBMITTER: Nunes EDC 

PROVIDER: S-EPMC8070065 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature