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Synthesis of 4-Arylselanyl-1H-1,2,3-triazoles from Selenium-Containing Carbinols.

ABSTRACT: In this work, we present a simple way to achieve 4-arylselanyl-1H-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols were used as starting materials to produce a range of selanyl-triazoles in moderate to good yields, including a quinoline and Zidovudine derivatives. One-pot protocols are crucial to the current concerns about waste production and solvent consumption, avoiding the isolation and purification steps of the reactive terminal selanylalkynes. We could also isolate an interesting and unprecedented by-product with one alkynylselenium moiety connected to the triazole.

SUBMITTER: Begini F

PROVIDER: S-EPMC8070154 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Synthesis of 4-Arylselanyl-1<i>H</i>-1,2,3-triazoles from Selenium-Containing Carbinols.

Begini Francesca F Balaguez Renata A RA Larroza Allya A Lopes Eric F EF Lenardão Eder João EJ Santi Claudio C Alves Diego D

Molecules (Basel, Switzerland) 20210412 8

In this work, we present a simple way to achieve 4-arylselanyl-1<i>H</i>-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols were used as starting materials to produce a range of selanyl-triazoles in moderate to good yields, including a quinoline and Zidovudine derivatives. One-pot protocols are crucial to the current concerns about waste production and solvent consumption, avoiding the isolation and purification steps of the reactive termi ...[more]

PMID: 33921473

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