Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme.

ABSTRACT: Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer's aggressive nature and resistance to current treatment options. This drives research into optimization algorithms for treatment planning as well as radiofrequency (RF) applicator design for treatment delivery. In this work, nine clinically realistic GBM target volumes (TVs) for thermal intervention are compared using three optimization algorithms and up to ten RF applicator designs for thermal magnetic resonance. Hyperthermia treatment planning (HTP) was successfully performed for all cases, including very small, large, and even split target volumes. Minimum requirements formulated for the metrics assessing HTP

SUBMITTER: Oberacker E 

PROVIDER: S-EPMC8070230 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature