The Effects of Functionally Guided, Connectivity-Based rTMS on Amygdala Activation.

ABSTRACT: While repetitive transcranial magnetic stimulation (rTMS) is widely used to treat psychiatric disorders, innovations are needed to improve its efficacy. An important limitation is that while psychiatric disorders are associated with fronto-limbic dysregulation, rTMS does not have sufficient depth penetration to modulate affected subcortical structures. Recent advances in task-related functional connectivity provide a means to better link superficial and deeper cortical sources with the possibility of increasing fronto-limbic modulation to induce stronger therapeutic effects. The objective of this pilot study was to test whether task-related, connectivity-based rTMS could modulate amygdala activation through its connectivity with the medial prefrontal cortex (mPFC). fMRI was collected to id

SUBMITTER: Beynel L 

PROVIDER: S-EPMC8070235 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature