Triazole-Resistance in Environmental Aspergillus fumigatus in Latin American and African Countries.

ABSTRACT: Triazole-resistance has been reported increasingly in Aspergillus fumigatus. An international expert team proposed to avoid triazole monotherapy for the initial treatment of invasive aspergillosis in regions with >10% environmental-resistance, but this prevalence is largely unknown for most American and African countries. Here, we screened 584 environmental samples (soil) from urban and rural locations in Mexico, Paraguay, and Peru in Latin America and Benin and Nigeria in Africa for triazole-resistant A. fumigatus. Samples were screened using triazole-containing agars and confirmed as triazole-resistant by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) broth dilution reference method. Isolates were further characterized by cyp51A sequencing and short-tandem repeat

SUBMITTER: Resendiz-Sharpe A 

PROVIDER: S-EPMC8070258 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature