Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species.

ABSTRACT: Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of "bridge hosts" in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus Plum pox virus (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two

SUBMITTER: Martinez-Turino S 

PROVIDER: S-EPMC8070427 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature