DNA methylation is associated with airflow obstruction in patients living with HIV.

ABSTRACT:

Introduction

People living with HIV (PLWH) suffer from age-related comorbidities such as COPD. The processes responsible for reduced lung function in PLWH are largely unknown. We performed an epigenome-wide association study to investigate whether blood DNA methylation is associated with impaired lung function in PLWH.

Methods

Using blood DNA methylation profiles from 161 PLWH, we tested the effect of methylation on FEV₁, FEV₁/FVC ratio and FEV₁ decline over a median of 5 years. We evaluated the global methylation of PLWH with airflow obstruction by testing the differential methylation of transposable elements Alu and LINE-1, a well-described marker of epigenetic ageing.

Results

Airflow obstruction as defined by a FEV₁/FVC<0

SUBMITTER: Hernandez Cordero AI 

PROVIDER: S-EPMC8070606 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature