Streptococcus australis and Ralstonia pickettii as Major Microbiota in Mesotheliomas.

ABSTRACT: The microbiota has been reported to be correlated with carcinogenesis and cancer progression. However, its involvement in the pathology of mesothelioma remains unknown. In this study, we aimed to identify mesothelioma-specific microbiota using resected or biopsied mesothelioma samples. Eight mesothelioma tissue samples were analyzed via polymerase chain reaction (PCR) amplification and 16S rRNA gene sequencing. The operational taxonomic units (OTUs) of the effective tags were analyzed in order to determine the taxon composition of each sample. For the three patients who underwent extra pleural pneumonectomy, normal peripheral lung tissues adjacent to the tumor were also included, and the same analysis was performed. In total, 61 OTUs were identified in the tumor and lung tissues, which wer

SUBMITTER: Higuchi R 

PROVIDER: S-EPMC8070724 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature