Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm.

ABSTRACT: Abdominal aortic aneurysm (AAA) is increasing due to aging of the population and is a major cause of death among the elderly. Ultrasound screening programs are useful in early diagnosis, but aneurysm size is not always a good predictor of rupture. Our aim was to analyze the value of circulating molecules related to oxidative stress and inflammation as new biomarkers to assist the management of AAA. The markers were quantified by ELISA, and their expression in the aneurysmal wall was studied by real-time PCR and by immunostaining. Correlation analysis of the studied markers with aneurysm diameter and peak wall stress (PWS), obtained by finite element analysis, and multivariate regression analysis to assess potential confounding factors were performed. Our study shows an extensive inflammato

SUBMITTER: Sanchez-Infantes D 

PROVIDER: S-EPMC8070751 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature