Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.

ABSTRACT: Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime example of the paradigms of a translocation-positive sarcoma: a genetically rather simple disease with a specific and neomorphic-potential therapeutic target, whose oncogenic role was irrefutably defined decades ago. This is a disease that by definition has micrometastatic disease at diagnosis and a dismal prognosis for patients with macrometastatic or recurrent disease. International collaborations have defined the current standard of care in prospective studies, delivering multiple cycles of systemic therapy combined with local treatment; both are associated with significant morbidity that may result in strong psychological and physical burden for survivors. Nevertheless, the combination of non-directed

SUBMITTER: Zollner SK 

PROVIDER: S-EPMC8071040 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature