Predictions of hypertrophy and its regression in response to pressure overload.

ABSTRACT: Mechanics-based cardiac growth models can now predict changes in mass, chamber size, and wall thickness in response to perturbations such as pressure overload (PO), volume overload, and myocardial infarction with a single set of growth parameters. As these models move toward clinical applications, many of the most interesting applications involve predictions of whether or how a patient's heart will reverse its growth after an intervention. In the case of PO, significant regression in wall thickness is observed both experimentally and clinically following relief of overload, for example following replacement of a stenotic aortic valve. Therefore, the objective of this work was to evaluate the ability of a published cardiac growth model that captures forward growth in multiple situations to

SUBMITTER: Yoshida K 

PROVIDER: S-EPMC8071348 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature