A Computational Investigation of In Vivo Cytosolic Protein Delivery for Cancer Therapy.

ABSTRACT: The ability to specifically block or degrade cytosolic targets using therapeutic proteins would bring tremendous therapeutic opportunities in cancer therapy. Over the last few years, significant progress has been made with respect to tissue targeting, cytosolic delivery, and catalytic inactivation of targets, placing this aim within reach. Here, we developed a mathematical model specifically built for the evaluation of approaches towards cytosolic protein delivery, involving all steps from systemic administration to translocation into the cytosol and target engagement. Focusing on solid cancer tissues, we utilized the model to investigate the effects of microvascular permeability, receptor affinity, the cellular density of targeted receptors, as well as the mode of activity (blocking/degra

SUBMITTER: Torres C 

PROVIDER: S-EPMC8071550 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature