Blood Transfusion and Adverse Graft-related Events in Kidney Transplant Patients.

ABSTRACT:

Background

The impact of posttransplant red blood cell transfusion (RBCT) and their potential immunomodulatory effects on kidney transplant recipients are unclear. We examined the risks for adverse graft outcomes associated with post-kidney transplant RBCT.

Methods

We conducted a retrospective cohort study of all adult kidney transplant recipients at The Ottawa Hospital from 2002 to 2018. The exposure of interest was receipt of an RBCT after transplant categorized as 1, 2, 3 to 5, and >5 RBC. Outcomes of interest were rejection and death-censored graft loss (DCGL). Cox proportional hazards models were used to calculate hazard ratios (HR) with RBCT as a time-varying, cumulative exposure.

Results

Among 1258 kidney transplant recipients, 468 (37.2%) received 2373 total R

SUBMITTER: Massicotte-Azarniouch D 

PROVIDER: S-EPMC8071620 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature