Risk for Significant Kidney Function Decline After Acute Kidney Injury in Adults With Hematologic Malignancy.

ABSTRACT:

Introduction

Acute kidney injury (AKI) affects 30% of adults hospitalized with hematologic malignancy. Little is known about the long-term impact on kidney outcomes in this population despite the close relationship between kidney function and malignancy treatment eligibility. The purpose of this population-based cohort study was to determine the effect of AKI on kidney function in the year following a new diagnosis of acute leukemia or lymphoma.

Methods

Participants were adults hospitalized within 3 weeks of malignancy diagnosis. Baseline kidney function was determined and AKI diagnosed using standardized criteria. Cox proportional hazard modeling examined the relationship between AKI and a ≥30% decline in estimated glomerular filtration rate (eGFR) from baseline in the 1 ye

SUBMITTER: May HP 

PROVIDER: S-EPMC8071647 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature