Pharmacokinetics of Vancomycin in Pediatric Patients Receiving Intermittent Hemodialysis or Hemodiafiltration.

ABSTRACT:

Introduction

Vancomycin is a common antibiotic used to treat hemodialysis (HD) or hemodiafiltration (HDF)-related infections in pediatric patients, but optimal dosing remains unknown. This is the first observational study to characterize the pharmacokinetics and evaluate dosing of vancomycin in this population.

Methods

Eligible patients received IV vancomycin 10 mg/kg per dose postdialysis followed by a series of serum vancomycin concentrations collected before, immediately after, 1 hour after, and 4 hours after dialysis. The pharmacokinetic parameters were estimated using 1- and 2-compartment models and a nonlinear least-squares algorithm.

Results

Among 42 vancomycin courses in 16 patients, 1 compartment model had the best fit for observed data. The net drug removal

SUBMITTER: Chung E 

PROVIDER: S-EPMC8071675 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature