Subversion of Host Innate Immunity by Rickettsia australis via a Modified Autophagic Response in Macrophages.

ABSTRACT: We recently reported that the in vitro and in vivo survivals of Rickettsia australis are Atg5-dependent, in association with an inhibited level of anti-rickettsial cytokine, IL-1β. In the present study, we sought to investigate how R. australis interacts with host innate immunity via an Atg5-dependent autophagic response. We found that the serum levels of IFN-γ and G-CSF in R. australis-infected Atg5^flox/flox Lyz-Cre mice were significantly less compared to Atg5^flox/flox mice, accompanied by significantly lower rickettsial loads in tissues with inflammatory cellular infiltrations including neutrophils. R. australis infection differentially regulated a significant number of genes in bon

SUBMITTER: Bechelli J 

PROVIDER: S-EPMC8071864 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature