Iron Metabolism: An Under Investigated Driver of Renal Pathology in Lupus Nephritis.

ABSTRACT: Nephritis is a common manifestation of systemic lupus erythematosus, a condition associated with inflammation and iron imbalance. Renal tubules are the work horse of the nephron. They contain a large number of mitochondria that require iron for oxidative phosphorylation, and a tight control of intracellular iron prevents excessive generation of reactive oxygen species. Iron supply to the kidney is dependent on systemic iron availability, which is regulated by the hepcidin-ferroportin axis. Most of the filtered plasma iron is reabsorbed in proximal tubules, a process that is controlled in part by iron regulatory proteins. This review summarizes tubulointerstitial injury in lupus nephritis and current understanding of how renal tubular cells regulate intracellular iron levels, highlighting t

SUBMITTER: Wlazlo E 

PROVIDER: S-EPMC8071941 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature