Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study.

ABSTRACT: Purpose: Emerging evidence suggests a potential role of interleukin-6 pathways-trans-signaling with soluble interleukin-6 receptors-in the asthma pathobiology. Despite the evidence for their associations with asthma, the causal role of soluble interleukin-6 receptors remains uncertain. We investigated the relations of soluble interleukin-6 receptors with asthma and its major phenotypes. Methods: We conducted a two-sample Mendelian randomization study. As genetic instruments, we selected 33 independent cis-acting variants strongly associated with the level of plasma soluble interleukin-6 receptor in the INTERVAL study. To investigate the association of variants with asthma and its phenotypes, we used genome-wide association study data from the UK Biobank. We combined va

SUBMITTER: Raita Y 

PROVIDER: S-EPMC8071981 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature