Identification of Expression Patterns and Potential Prognostic Significance of m⁵C-Related Regulators in Head and Neck Squamous Cell Carcinoma.

ABSTRACT: 5-Methylcytosine (m⁵C) methylation is a major epigenetic technique of RNA modification and is dynamically mediated by m⁵C "writers," "erasers," and "readers." m⁵C RNA modification and its regulators are implicated in the onset and development of many tumors, but their roles in head and neck squamous cell carcinoma (HNSCC) have not yet been completely elucidated. In this study, we examined expression patterns of core m⁵C regulators in the publicly available HNSCC cohort via bioinformatic methods. The differentially expressed m⁵C regulators could divide the HNSCC cohort into four subgroups with distinct prognostic characteristics. Furthermore, a three-gene expression signature model, comprised of NSUN5, DNMT1, and DNMT3A, was esta

SUBMITTER: Han Z 

PROVIDER: S-EPMC8072008 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature