High Rates of Genome Rearrangements and Pathogenicity of Shigella spp.

ABSTRACT: Shigella are pathogens originating within the Escherichia lineage but frequently classified as a separate genus. Shigella genomes contain numerous insertion sequences (ISs) that lead to pseudogenisation of affected genes and an increase of non-homologous recombination. Here, we study 414 genomes of E. coli and Shigella strains to assess the contribution of genomic rearrangements to Shigella evolution. We found that Shigella experienced exceptionally high rates of intragenomic rearrangements and had a decreased rate of homologous recombination compared to pathogenic and non-pathogenic E. coli. The high rearrangement rate resulted in independent disruption of syntenic regions and parallel rearrangements in different Shigella line

SUBMITTER: Seferbekova Z 

PROVIDER: S-EPMC8072062 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature