Case Report: Next-Generation Sequencing Reveals Tumor Origin in a Female Patient With Brain Metastases.

ABSTRACT:

Background

Brain metastasis mainly originates from lung cancer. Napsin A and TTF-1 factors have frequently been detected in lung adenocarcinoma cases. Brain metastasis tumors with napsin A and TTF-1 positive are easily classified as lung adenocarcinoma origin. However, some thyroid cancers also exhibit these clinical features. Besides, lung is the most common metastasis of undifferential thyroid cancer. Therefore, it requires development of novel diagnostic tools to aid in distinguishing between pulmonary and thyroid origin.

Patient findings

We reported a case that was initially diagnosed as brain metastatic lung cancer based on immunohistochemistry results. Analysis of next-generation sequencing (NGS) data from the brain lesion revealed that the cancer may have originated f

SUBMITTER: Li Q 

PROVIDER: S-EPMC8072118 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature