An autopsy study of the spectrum of severe COVID-19 in children: From SARS to different phenotypes of MIS-C.

ABSTRACT:

Background

COVID-19 in children is usually mild or asymptomatic, but severe and fatal paediatric cases have been described. The pathology of COVID-19 in children is not known; the proposed pathogenesis for severe cases includes immune-mediated mechanisms or the direct effect of SARS-CoV-2 on tissues. We describe the autopsy findings in five cases of paediatric COVID-19 and provide mechanistic insight into the mechanisms involved in the pathogenesis of the disease.

Methods

Children and adolescents who died with COVID-19 between March 18 and August 15, 2020 were autopsied with a minimally invasive method. Tissue samples from all vital organs were analysed by histology, electron microscopy (EM), reverse-transcription polymerase chain reaction (RT-PCR) and immunohistochemistry (

SUBMITTER: Duarte-Neto AN 

PROVIDER: S-EPMC8072136 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature