Depletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins.

ABSTRACT:

Background

Gastric carcinoma (GC) is a digestive system disease with high morbidity and mortality. However, early clinical detection is difficult, and the therapeutic effect for advanced disease is not satisfactory. Thus, finding new tumor markers and therapeutic targets conducive to the treatment of GC is imperative. MRPL35 is a member of the large subunit family of mitochondrial ribosomal protein. MRPL35 shows the characteristic of oncogene in colorectal cancer and esophageal cancer, which promotes the exploration of the correlation between MRPL35 and GC. We proposed that the expression of MRPL35 might be critical in GC.

Aim

To study the effect of MRPL35 knockdown on GC cell proliferation.

Methods

The expression of MRPL35 in GC was evaluated based on d

SUBMITTER: Yuan L 

PROVIDER: S-EPMC8072187 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature