E2A-regulated epigenetic landscape promotes memory CD8 T cell differentiation.

ABSTRACT: During an acute viral infection, CD8 T cells encounter a myriad of antigenic and inflammatory signals of variable strength, which sets off individual T cells on their own differentiation trajectories. However, the developmental path for each of these cells will ultimately lead to one of only two potential outcomes after clearance of the infection-death or survival and development into memory CD8 T cells. How this cell fate decision is made remains incompletely understood. In this study, we explore the transcriptional changes during effector and memory CD8 T cell differentiation at the single-cell level. Using single-cell, transcriptome-derived gene regulatory network analysis, we identified two main groups of regulons that govern this differentiation process. These regulons function in con

SUBMITTER: Schauder DM 

PROVIDER: S-EPMC8072256 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature