The Affinity of Hemoglobin for Oxygen Is Not Altered During COVID-19.

ABSTRACT: Background: A computational proteomic analysis suggested that SARS-CoV-2 might bind to hemoglobin (Hb). The authors hypothesized that this phenomenon could result in a decreased oxygen (O₂) binding and lead to hemolytic anemia as well. The aim of this work was to investigate whether the affinity of Hb for O₂ was altered during COVID-19. Methods: In this retrospective, observational, single-center study, the blood gas analyses of 100 COVID-19 patients were compared to those of 100 non-COVID-19 patients. Fifty-five patients with carboxyhemoglobin (HbCO) ≥8% and 30 with sickle cell disease (SCD) were also included ("positive controls" with abnormal Hb affinity). P₅₀ was corrected for body temperature, pH, and PCO₂. Results: Pati

SUBMITTER: Gille T 

PROVIDER: S-EPMC8072381 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature