3D PCL/Gelatin/Genipin Nanofiber Sponge as Scaffold for Regenerative Medicine.

ABSTRACT: Recent advancements in tissue engineering and material science have radically improved in vitro culturing platforms to more accurately replicate human tissue. However, the transition to clinical relevance has been slow in part due to the lack of biologically compatible/relevant materials. In the present study, we marry the commonly used two-dimensional (2D) technique of electrospinning and a self-assembly process to construct easily reproducible, highly porous, three-dimensional (3D) nanofiber scaffolds for various tissue engineering applications. Specimens from biologically relevant polymers polycaprolactone (PCL) and gelatin were chemically cross-linked using the naturally occurring cross-linker genipin. Potential cytotoxic effects of the scaffolds were analyzed by culturing human dermal

SUBMITTER: Merk M 

PROVIDER: S-EPMC8072632 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature