Direct Measurement of Sedimentation Coefficient Distributions in Multimodal Nanoparticle Mixtures.

ABSTRACT: Differential centrifugal sedimentation (DCS) is based on physical separation of nanoparticles in a centrifugal field prior to their analysis. It is suitable for resolving particle populations, which only slightly differ in size or density. Agglomeration presents a common problem in many natural and engineered processes. Reliable data on the agglomeration state are also crucial for hazard and risk assessment of nanomaterials and for grouping and read-across of nanoforms. Agglomeration results in polydisperse mixtures of nanoparticle clusters with multimodal distributions in size, density, and shape. These key parameters affect the sedimentation coefficient, which is the actual physical quantity measured in DCS, although the method is better known for particle sizing. The conversion into a p

SUBMITTER: Pluisch CS 

PROVIDER: S-EPMC8072784 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature