Integration of Multiple Resolution Data in 3D Chromatin Reconstruction Using ChromStruct.

ABSTRACT: The three-dimensional structure of chromatin in the cellular nucleus carries important information that is connected to physiological and pathological correlates and dysfunctional cell behaviour. As direct observation is not feasible at present, on one side, several experimental techniques have been developed to provide information on the spatial organization of the DNA in the cell; on the other side, several computational methods have been developed to elaborate experimental data and infer 3D chromatin conformations. The most relevant experimental methods are Chromosome Conformation Capture and its derivatives, chromatin immunoprecipitation and sequencing techniques (CHIP-seq), RNA-seq, fluorescence in situ hybridization (FISH) and other genetic and biochemical techniques. All of them pro

SUBMITTER: Caudai C 

PROVIDER: S-EPMC8072831 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature