MicroRNA in Human Acute Kidney Injury: A Systematic Review Protocol.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common complication of hospitalization with high morbidity and mortality for which no effective treatments exist and for which current diagnostic tools have limitations for earlier identification. MicroRNAs (miRNAs) are small non-coding RNAs that have been implicated in the pathogenesis of AKI, and some miRNAs have shown promise as therapeutic tools in animal models of AKI. However, less is known about the role of miRNAs in human AKI.

Objective

To evaluate the role of miRNAs in human subjects with AKI.

Design

Systematic review and meta-analysis.

Measurements

Quantification of miRNA levels from human blood, urine, or kidney biopsy samples, and measures of renal function as defined in the study protocol.

Methods

A

SUBMITTER: Douvris A 

PROVIDER: S-EPMC8072838 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature