Dalfampridine improves slowed processing speed in multiple sclerosis patients with mild motor disability: post hoc analysis of a randomized controlled trial.

ABSTRACT:

Objective

To evaluate baseline characteristics predictive of improving information processing speed in multiple sclerosis (MS) and the relationship between cognitive and motor response to dalfampridine (DA) treatment.

Methods

This is a post hoc analysis of a randomized, double-blind, placebo-controlled trial in patients with MS randomized to receive DA 10 mg or placebo twice daily for 12 consecutive weeks. Here, we include only data from 71 patients in the arm treated with DA. According to the median value of Symbol Digit Modalities Test (SDMT) response, patients were categorized as "full responders" (FR) or "partially responders" (PR).

Results

There was higher possibility of being FR in the presence of a baseline lower Expanded Disability Status Scale [odds ratio (OR

SUBMITTER: Pozzilli C 

PROVIDER: S-EPMC8072854 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature