Thermodynamic Evaluation of the Interactions between Anticancer Pt(II) Complexes and Model Proteins.

ABSTRACT: In this work, we have analysed the binding of the Pt(II) complexes ([PtCl(4'-phenyl-2,2':6',2″-terpyridine)](CF₃SO₃) (1), [PtI(4'-phenyl-2,2':6',2″-terpyridine)](CF₃SO₃) (2) and [PtCl(1,3-di(2-pyridyl)benzene) (3)] with selected model proteins (hen egg-white lysozyme, HEWL, and ribonuclease A, RNase A). Platinum coordination compounds are intensively studied to develop improved anticancer agents. In this regard, a critical issue is the possible role of Pt-protein interactions in their mechanisms of action. Multiple techniques such as differential scanning calorimetry (DSC), electrospray ionization mass spectrometry (ESI-MS) and UV-Vis absorbance titrations were used to enlighten the details of the binding to the different bio

SUBMITTER: Pelosi C 

PROVIDER: S-EPMC8072931 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature