A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer.

ABSTRACT: Outcomes for men with localized prostate cancer vary widely, with some men effectively managed without treatment on active surveillance, while other men rapidly progress to metastatic disease despite curative-intent therapies. One of the strongest prognostic indicators of outcome is grade groups based on the Gleason grading system. Gleason grade 4 prostate cancer with cribriform morphology is associated with adverse outcomes and can be utilized clinically to improve risk stratification. The underpinnings of disease aggressiveness associated with cribriform architecture are not fully understood. Most studies have focused on genetic and molecular alterations in cribriform tumor cells; however, less is known about the tumor microenvironment in cribriform prostate cancer. Cancer-associated fib

SUBMITTER: Hesterberg AB 

PROVIDER: S-EPMC8073007 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature