Caffeine-Cyclodextrin Complexes as Solids: Synthesis, Biological and Physicochemical Characterization.

ABSTRACT: Mechanochemical and in-solution synthesis of caffeine complexes with α-, β-, and γ-cyclodextrins was optimized. It was found that short-duration, low-energy cogrinding, and evaporation (instead of freeze-drying) are effective methods for the formation and isolation of these complexes. The products obtained, their pure components, and their mixtures were examined by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), FT-IR and Raman spectroscopy. Moreover, molecular modeling provided an improved understanding of the association process between the guest and host molecules in these complexes. The complexes were found to exhibit high toxicity in zebrafish (Danio rerio) embryos, in contrast to pure caffeine and cyclodextrins at the same molar concentrations. HPLC measurem

SUBMITTER: Szmeja S 

PROVIDER: S-EPMC8073077 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature