SARS-CoV-2 M^pro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors.

ABSTRACT: The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS-CoV-2 during 2020-2021 is one of the most devastating events in the history, with remarkable impacts on the health, economic systems, and habits of the entire world population. While some effective vaccines are nowadays approved and extensively administered, the long-term efficacy and safety of this line of intervention is constantly under debate as coronaviruses rapidly mutate and several SARS-CoV-2 variants have been already identified worldwide. Then, the WHO's main recommendations to prevent severe clinical complications by COVID-19 are still essentially based on social distancing and limitation of human interactions, therefore the identification of new target-based drugs became a priority. Several stra

SUBMITTER: Citarella A 

PROVIDER: S-EPMC8073203 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature