Diverse Roles of Mitochondria in Renal Injury from Environmental Toxicants and Therapeutic Drugs.

ABSTRACT: Mitochondria are well-known to function as the primary sites of ATP synthesis in most mammalian cells, including the renal proximal tubule. Other functions have also been associated with different mitochondrial activities, including the regulation of redox status and the initiation of mitophagy and apoptosis. Mechanisms for the membrane transport of glutathione (GSH) and various GSH-derived metabolites across the mitochondrial inner membrane of renal proximal tubular cells are critical determinants of these functions and may serve as pharmacological targets for potential therapeutic approaches. Specific interactions of reactive intermediates, derived from drug metabolism, with molecular components in mitochondria have been identified as early steps in diverse forms of chemically-induced ne

SUBMITTER: Lash LH 

PROVIDER: S-EPMC8073222 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature