Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis.

ABSTRACT:

Objective

The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to platelets and erythrocytes. Activated cells release submicron extracellular vesicles (EV) that transport molecules from the donor cell. In rheumatoid arthritis, EV accumulate in the joint where they can interact with numerous cellular lineages. However, whether EV can exit the inflamed tissue to recirculate is unknown. Here, we investigated whether vascular leakage that occurs during inflammation could favor EV access to the lymphatic system. Approach and Results: Using an in vivo model of autoimmune inflammatory arthritis, we show that there is an inf

SUBMITTER: Tessandier N 

PROVIDER: S-EPMC8073225 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature