Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non-small cell lung cancer.

ABSTRACT:

Objectives

Ki67 is a marker for tumor proliferative activity and is known to have prognostic significance in multiple solid malignancies. We sought to characterize the relationships among Ki67 expression, immune cell infiltration, and immune checkpoint expression in patients with resected non-small cell lung cancer.

Methods

Specimens of patients undergoing resection of stage I to III non-small cell lung cancer (1997-2012) were analyzed using tissue microarrays. Proliferative index was quantified as the percentage of malignant cells expressing Ki67. Checkpoints expressed on malignant cells (programmed death ligand 1, B7H3, B7H4, indoleamine 2,3-dioxygenase 1) and lymphocytes (T-cell immunoglobulin and mucin-domain containing 3, V-domain suppressor of T-cell activation, tumor

SUBMITTER: Mitchell KG 

PROVIDER: S-EPMC8073227 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature