Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.

ABSTRACT: Long duration spaceflight poses potential health risks to astronauts during flight and re-adaptation after return to Earth. There is an emerging need for NASA to provide successful and reliable therapeutics for long duration missions when capability for medical intervention will be limited. Clinically relevant, human placenta-derived therapeutic stromal cells (PLX-PAD) are a promising therapeutic alternative. We found that treatment of adult female mice with PLX-PAD near the onset of simulated weightlessness by hindlimb unloading (HU, 30 d) was well-tolerated and partially mitigated decrements caused by HU. Specifically, PLX-PAD treatment rescued HU-induced thymic atrophy, and mitigated HU-induced changes in percentages of circulating neutrophils, but did not rescue changes in the percenta

SUBMITTER: Rubinstein L 

PROVIDER: S-EPMC8073415 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature