Genetic Determinants of Poor Response to Treatment in Severe Asthma.

ABSTRACT: Severe asthma is a multifactorial disorder with marked phenotypic heterogeneity and complex interactions between genetics and environmental risk factors, which could, at least in part, explain why during standard pharmacologic treatment, many patients remain poorly controlled and at an increased risk of airway remodeling and disease progression. The concept of "precision medicine" to better suit individual unique needs is an emerging trend in the management of chronic respiratory diseases. Over the past few years, Genome-Wide Association Studies (GWAS) have revealed novel pharmacogenetic variants related to responses to inhaled corticosteroids and the clinical efficacy of bronchodilators. Optimal clinical response to treatment may vary between racial/ethnic groups or individuals due to gen

SUBMITTER: Figueiredo RG 

PROVIDER: S-EPMC8073667 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature