Imbalance of Mg Homeostasis as a Potential Biomarker in Colon Cancer.

ABSTRACT: Increasing evidences support a correlation between magnesium (Mg) homeostasis and colorectal cancer (CRC). Nevertheless, the role of Mg and its transporters as diagnostic markers in CRC is still a matter of debate. In this study we combined X-ray Fluorescence Microscopy and databases information to investigate the possible correlation between Mg imbalance and CRC. CRC tissue samples and their non-tumoural counterpart from four patients were collected and analysed for total Mg level and distribution by X-Ray Fluorescence Microscopy. We also reviewed the scientific literature and the main tissue expression databases to collect data on Mg transporters expression in CRC. We found a significantly higher content of total Mg in CRC samples when compared to non-tumoural tissues. Mg distribution wa

SUBMITTER: Schiroli D 

PROVIDER: S-EPMC8073761 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature