Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2.

ABSTRACT: Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve transmission, and the induction of muscle necrosis. The biological properties of these proteins are not only due to their enzymatic activity, but also to protein-protein interactions which are still unidentified. Here, we compare sequence alignments of snake venom and mammalian PLA2s, grouped according to their structure and biological activity, looking for differences that can justify their different behavior. This bioinformatics analysis has evidenced three distinct regions, two central and one C-terminal, having amino acid compositions that disting

SUBMITTER: Peggion C 

PROVIDER: S-EPMC8073766 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature