Telomere Architecture Correlates with Aggressiveness in Multiple Myeloma.

ABSTRACT: The prognosis of multiple myeloma (MM), an incurable B-cell malignancy, has significantly improved through the introduction of novel therapeutic modalities. Myeloma prognosis is essentially determined by cytogenetics, both at diagnosis and at disease progression. However, for a large cohort of patients, cytogenetic analysis is not always available. In addition, myeloma patients with favorable cytogenetics can display an aggressive clinical course. Therefore, it is necessary to develop additional prognostic and predictive markers for this disease to allow for patient risk stratification and personalized clinical decision-making. Genomic instability is a prominent characteristic in MM, and we have previously shown that the three-dimensional (3D) nuclear organization of telomeres is a marker

SUBMITTER: Rangel-Pozzo A 

PROVIDER: S-EPMC8073772 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature