Dexamethasone-Loaded Bioactive Coatings on Medical Grade Stainless Steel Promote Osteointegration.

ABSTRACT: In this study, a multilayer bioactive coating based on carboxymethyl cellulose (CMC) and dexamethasone (DEX) was prepared on medical-grade stainless steel (AISI 316LVM). Its aim was the controlled drug delivery of the incorporated anti‑inflammatory drug, which at the same time promotes osteogenic differentiation of mesenchymal stem cells. Due to DEX's limited solubility in physiological fluids, which limits the loading capacity of coatings, it was further combined with β-cyclodextrin to increase its concentration in the bioactive coating. Controlled release of DEX from the multilayer coating was achieved in four steps: a "burst", i.e., very fast, release step (in an immersion interval of 0-10 min), a fast release step (10-30 min), a slow-release step (60-360 min), and a plateau step (360-4

SUBMITTER: Rozanc J 

PROVIDER: S-EPMC8073817 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature